Postmenopausal Asymptomatic Endometrial Thickening
Journal of Women’s Health and Reproductive Medicine mainly focuses on research on pregnancy, menopause, prenatal care, breast cancer, urinary tract infections, menstruation irregularities, childbirth, and reproductive endocrinology.
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Finding of asymptomatic postmenopausal endometrial thickening on ultrasonography presents a frequent reason for referral by young clinicians and considered as a clinical-management problem because there is no consensus about best management. Also, underlying factors for endometrial thickening not well defined. To determine the relationship between risk factors and asymptomatic postmenopausal endometrial thickening, and to characterize endometrial pathology in women with an endometrial thickening. A cohort study was carried out on 146 consecutive postmenopausal women without vaginal bleeding, who were allocated according to endometrial thickness into two groups: ≥ 5 mm (Group A) and <5 mm (Group B) endometrial thickness. Study outcomes were differences between levels or distributions of risk factors between these groups and the endometrial pathology of those with a thickening. In Group A, endometrial thickness (mean ± SD) was 8.4 ± 3.9 mm. In Group B, endometrial thickness was 2.8 ± 0.6 mm. Compared with Group A, Group B had a higher mean age (75.6 years versus 53.9 years, p<0.001) and mean parity (4.8 versus 4.1, p<0.04), and a longer time since menopause (9.2 years versus 6.3 years, p<0.006). Group A had a higher percentage of women who experienced early menopause (52.1% versus 26.0%), and a higher mean body mass index (32.4 kg/m2 versus 30.30 kg/m2, p<0.001). The histopathological examination results of Group A included 49.3% simple endometrial hyperplasia, 6.8% hyperplasia with a typia and 4.1% endometrial carcinoma. Endometrial carcinoma and atypia are present in a proportion of asymptomatic postmenopausal women with a thickened endometrium (≥ 5 mm). Endometrial thickness (above or below 5 mm) seems related to several risk factors.
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Journal of Women's Health and Reproductive Medicine