The 2019â€new coronavirus epidemic: Evidence for virus evolution
There is a worldwide concern about the new coronavirus 2019â€nCoV as a global public health threat. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019â€nCoV, 12 whole genome sequences of 2019â€nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARSâ€like coronavirus).
Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019â€nCoV significantly clustered with bat SARSâ€like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019â€nCoV is distinct from SARS virus, probably transmitted from bats after mutation conferring ability to infect humans.
- An epidemic by a new Coronavirus, the 2019â€nCoV is worrying worldwide.
- The epidemic originated in Wuhan, China causing severe infections in some cases.
- The infection probably originated in bats.
- A mutation in the viral spike glycoprotein could have favored the crossâ€species transmission from bats to human.
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